New guidelines prioritize systemic therapy for colorectal cancer with peritoneal metastases

Consensus guidelines for managing colorectal cancer with peritoneal metastases emphasize early referral to specialized centers. A national panel achieved over 90% consensus on clinical pathways, favoring systemic therapy over upfront surgery in synchronous cases. In metachronous cases, risk stratification was updated. Although the overall evidence remains low, the guidelines represent significant progress in addressing optimal treatment strategies for this challenging condition, while highlighting the necessity for more robust research.