In patients with colorectal peritoneal metastases (CRC-PM) treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), systemic chemotherapy (SC) did not significantly enhance overall survival (OS). However, the timing of SC made a difference. Preoperative SC correlated with more major complications and shorter disease-free intervals, while postoperative SC resulted in longer disease-free intervals. The study emphasizes the need for randomized trials to clarify the role and timing of SC in this patient subset.
Journal Article by Tonello M, Baratti D (…) Sommariva A et 26 al. in Ann Surg Oncol
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