In the quest to predict diverticular disease’s course, researchers harnessed genetic insights. They developed a polygenic risk score based on prior genome-wide studies and tested it on nearly 61,000 patients. This score effectively stratified individuals by their risk of diverticulosis and diverticulitis, with significant differences between high and low-risk groups. It also improved recurrent diverticulitis risk prediction compared to clinical factors alone. These findings suggest that alongside other factors, a polygenic risk score could guide discussions, potentially impacting surgical decisions for high-risk patients.
Journal Article by Schaeffer HD, Smelser DT (…) Hoffman RL et 5 al. in Dis Colon Rectum
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