Irreversible Electroporation for Pancreatic Cancer: A Safer Alternative

A multi-institutional analysis of patients with locally advanced pancreatic cancer revealed that irreversible electroporation (IRE), a novel treatment, resulted in a lower rate of adverse events (25%) compared to pancreatectomy (39%) for early-stage disease. IRE patients had a greater risk of severe complications when they received high-dose neoadjuvant radiation, had electrodes close to vital blood vessels, or had bile duct stents for over six months. While IRE presents challenges, understanding its unique adverse events is vital for the care of patients.