In a study on non-metastatic colon cancer patients, researchers explored conditional overall survival (COS) considering laterality, microsatellite instability (MSI), and KRAS mutation status. Among 4,838 patients, those with mutated KRAS experienced worse COS, implying a more aggressive disease course, with a higher risk of death 2 years post-diagnosis. While laterality and MSI status didn’t significantly affect COS, evaluating KRAS status could aid in prognosis and identifying individuals who may benefit from modified follow-up protocols.
Journal Article by Tran CG, Goffredo P (…) Hassan I et 5 al. in Ann Surg Oncol
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