Endoscopic Ultrasound-guided Nerve Block Shows Promise in Easing Pancreatic Cancer Pain

In a network meta-analysis of ten randomized controlled trials, researchers assessed the effectiveness of endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) in addition to medical management for abdominal pain in unresectable pancreatic cancer. Results favored EUS-CPN combined with medical management, showing significantly reduced pain intensity at 4 and 12 weeks compared to medical management alone or other techniques like percutaneous CPN. While promising, the study acknowledges the need for cautious interpretation due to potential bias in the analyzed trials.