This study explores the role of thyroid hormones (TH) and their receptor, TRα, in hepatic fibrogenesis, a key process in chronic liver disease. Researchers found that TRα plays a dominant role in hepatic stellate cells (HSC) and can modulate fibrogenic gene expression. TH, specifically T3, inhibited fibrogenic responses in HSC and reduced liver fibrogenesis in mice. This discovery highlights the potential of targeting the TH-TRα axis as a novel approach for treating liver fibrosis, offering hope for future therapies in chronic liver disease management.
Journal Article by Manka P, Coombes JD (…) Syn WK et 18 al. in Liver Int
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