Synthetic Mesh Holds Its Own: Comparable Efficacy and Safety for Incisional Hernia Prevention in the Preloop Trial

In the “Preloop Trial,” where 102 patients underwent loop ileostomy closure, researchers compared retrorectus synthetic mesh to biological mesh for preventing incisional hernia. At 10 months, both groups showed similar low rates of incisional hernia—2% each. No significant differences were found in complications, reoperation, operating time, or hospital stay. This suggests synthetic mesh is as effective and safe as biological mesh in preventing incisional hernia during loop ileostomy closure.