In the battle against adrenocortical carcinoma (ACC), researchers find surgical approach and extent matter less than tumor biology and margins in non-metastatic cases. A cohort study (2010–2019, 1,175 subjects) reveals laparoscopic surgery, often considered minimally invasive, correlates with worse survival in advanced disease (stage III). Positive margins negatively impact survival, while chemoradiation benefits those with such margins. Tumor biology emerges as the primary survival determinant, redirecting focus in ACC management.
Journal Article by Passman JE, Amjad W (…) Wachtel H et 2 al. in Ann Surg Oncol
© 2023. Society of Surgical Oncology.