Prophylactic Dexamethasone in Hepatectomy with 25-Min Intermittent Pringle’s Maneuver for Hepatocellular Carcinoma: A Randomized Trial

In hepatectomy for hepatocellular carcinoma (HCC) using a 25-minute Intermittent Pringle’s Maneuver (IPM), preoperative dexamethasone administration demonstrated benefits. The study included 270 patients, with the dexamethasone group exhibiting reduced hepatocellular injury, inflammatory response, and major complications, along with shorter hospital stays compared to the control group. Notably, subgroup analyses indicated milder hepatocellular injury for cirrhotic patients and reduced inflammatory response for non-cirrhotic patients. Preoperative dexamethasone administration proved effective in improving perioperative outcomes in HCC patients undergoing hepatectomy with a 25-minute IPM.