Skin wound healing often leads to abnormal scarring, such as keloids or hypertrophic scars, impacting millions globally. While the precise mechanisms remain elusive, evidence suggests ongoing inflammation in susceptible individuals perpetuates extracellular matrix changes, resulting in fibrotic lesions. Abnormal scarring, causing pain, functional impairment, and aesthetic concerns, lacks effective treatment. The study underscores the urgent need for standardized and innovative approaches to enhance outcomes in patients with pathological scarring.
Review by Jeschke MG, Wood FM (…) Gauglitz GG et 4 al. in Nat Rev Dis Primers
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