Margin Clearance and Survival in Ampullary Adenocarcinoma After Pancreaticoduodenectomy

Examining 128 patients undergoing pancreaticoduodenectomy for ampullary adenocarcinoma, Danish researchers found that a margin clearance of ≥1 mm was independently associated with significantly improved survival compared to <1 mm. Notably, posterior and anterior margins held isolated prognostic significance, emphasizing their particular importance in predicting outcomes. The study underscores the prognostic relevance of margin clearance in this context, shedding light on critical factors influencing survival after surgery for ampullary adenocarcinoma.