Combined Hepatic Resection and Ablation Ensure Safety and Long-Term Survival in Extensive Colorectal Liver Metastases

Examining 161 patients with colorectal liver metastases (CRLM), researchers investigated the safety and efficacy of simultaneous hepatic resection (HR) and ablation. With 77.6% having bilobar disease and 57.1% having ≥5 tumors, the combined procedure demonstrated acceptable safety and durable long-term survival (median 38.2 months, 5-year OS 33.2%). Simultaneous colon resection increased complications. Importantly, patients with a high tumor burden (≥5 tumors) had comparable survival to those with fewer tumors. This study supports the viability of HR + ablation for managing extensive CRLM.