Laparoscopic pancreatoduodenectomy (LPD) is feasible and as safe and efficient as open pancreatoduodenectomy (OPD) when performed by highly skilled surgeons in high-volume centers

LPD and OPD were compared in this study, and it was found that LPD is feasible and equally safe and efficient as OPD when performed by highly skilled surgeons in high-volume centers. LPD has a shorter length of hospital stay, shorter ICU stay, lower blood loss, lower blood transfusion rate, and lower surgical site infection rate. However, LPD has a longer duration of operation. The overall certainty of the evidence was moderate.