Researchers conducted a systematic review and network meta-analysis to determine the optimal timing and intervention for reducing mortality in necrotizing pancreatitis. They analyzed 10 studies involving 570 patients and compared 8 treatment strategies. While no statistically significant differences were found in odds ratios, trends were confirmed by the surface under the cumulative ranking scores. The delayed surgical step-up approach (DSU) consistently performed the best in terms of reducing mortality and major complications. The study emphasizes avoiding drainage alone and postponing interventions for at least 4 weeks if possible.
Research Support, Non-U.S. Gov’t by Yang Y, Zhang Y, Wen S and Cui Y in World J Emerg Surg
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