Researchers evaluated the correlation between successful patient-derived xenograft (PDX) engraftment and survival in pancreaticobiliary cancer. They implanted 384 PDX models and found a 41% engraftment rate. Successful engraftment was strongly associated with both recurrence-free survival and overall survival outcomes. Furthermore, successful PDX tumor generation occurred significantly earlier than clinical recurrences. These findings suggest that successful PDX models can predict recurrence and survival across tumor types and may provide crucial lead time to modify surveillance or treatment plans before cancer recurrence.
Journal Article by Lynch IT, Abdelrahman AM (…) Truty MJ et 4 al. in J Am Coll Surg
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons.