High Mortality and Morbidity Rates in Patients at High Risk for Postoperative Pancreatic Fistula

Researchers analyzed nationwide outcomes after pancreatoduodenectomy in patients at very high risk for postoperative pancreatic fistula (POPF). The study found a 4.1% in-hospital mortality rate and observed major morbidity in 45.9% of patients. POPF occurred in 30% of patients, leading to increased major morbidity and mortality rates. Prophylactic total pancreatectomy (TP) was performed in only 2.1% of patients. The study suggests that while mortality rates remain significant, future trials should focus on preventing and managing POPF in this high-risk patient category.