Radical resection provides improved OS for patients with high-risk histology in T2N0M0 rectal adenocarcinoma
Local excision may be a reasonable approach for patients with low-risk histopathology and clinical stage T2N0M0 rectal adenocarcinoma, as it showed similar overall survival rates compared to radical resection. However, radical resection provided a significant survival advantage for patients with high-risk histology.
A Japanese randomized trial found that a 14-day schedule of trifluridine-tipiracil plus bevacizumab keeps patients with metastatic colorectal cancer alive as long as the standard 28-day schedule, with far less toxicity.
Five years after surgery for low rectal cancer, patients operated on robotically did as well as those operated on laparoscopically, according to a randomized trial from three Korean centres.