High-grade Tumors Increase Lymph Node Metastasis Risk in T1 and T2 Colorectal Cancer
Out of 765 patients with T1 and T2 colorectal cancer, 11.3% had lymph node metastasis (LNM), leading to a poorer recurrence-free survival (RFS) compared to patients without LNM (72.6% vs. 88.6%). Multivariable analysis revealed that high-grade tumors were a significant risk factor for LNM. Radical surgery should be considered for T1 and T2 colorectal cancer patients with high-grade tumors to improve their prognosis.
A Japanese randomized trial found that a 14-day schedule of trifluridine-tipiracil plus bevacizumab keeps patients with metastatic colorectal cancer alive as long as the standard 28-day schedule, with far less toxicity.
Five years after surgery for low rectal cancer, patients operated on robotically did as well as those operated on laparoscopically, according to a randomized trial from three Korean centres.