The study investigated the impact of genotype and surgical approach on long-term postoperative outcomes in patients with primary hyperparathyroidism and multiple endocrine neoplasia type 1 (MEN1). Findings showed that patients with protein-truncating germline pathogenic variants in specific exons of the MEN1 gene had aggressive pancreatic neuroendocrine tumors and earlier onset of primary hyperparathyroidism. The choice of surgical approach also affected disease-free survival, with subtotal parathyroidectomy associated with better outcomes compared to total parathyroidectomy. It is recommended to exercise caution when opting for subtotal parathyroidectomy in patients with specific MEN1 variants.
Journal Article by Shariq OA, Abrantes VB (…) McKenzie TJ et 6 al. in BMC Surg
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