Neoadjuvant treatment (NCRT) may not be necessary for all patients with T3 rectal cancer. This study compared the outcomes of patients with mid-low rectal cancer treated with either surgery alone or NCRT followed by surgery. After analyzing 1,509 patients, the study found that surgery alone provided similar long-term outcomes to NCRT followed by surgery. While NCRT offered advantages in sphincter-preserving surgery and tumor downstaging, it also resulted in a higher rate of enterostomies. Therefore, NCRT may lead to overtreatment in some patients.
Journal Article by Zeng Z, Li Z (…) Kang L et 7 al. in J Gastroenterol Hepatol
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