Which Antibiotic Regimen Fails in Nonoperative Treatment of Diverticulitis and Appendicitis?

Empiric antibiotic treatment of appendicitis is more likely to be associated with the need for additional antibiotics or procedure within 90 days compared to diverticulitis. Cephalosporin + metronidazole (c + m) was the most commonly used antibiotic regimen for appendicitis, while quinolone + metronidazole was more commonly used for diverticulitis. Treatment with c + m for diverticulitis was more likely to be correlated with the need for additional antibiotics or procedures within 90 days. However, the choice of antibiotic did not affect the rate of death for both conditions.