Gad2 immunohistochemistry is a highly specific diagnostic tool for identifying pancreatic origin in neuroendocrine neoplasms

Researchers analyzed a large number of tissue samples and found that gad2 immunohistochemistry is a highly specific diagnostic marker for neuroendocrine neoplasms of the pancreas. The expression of gad2 was only observed in a few normal cell types, making it a potential diagnostic tool. It was found to be most commonly seen in neuroendocrine carcinomas and tumors of the pancreas, followed by other tumor entities. Combining gad2 with progesterone receptor expression increased both sensitivity and specificity for determining a pancreatic origin in neuroendocrine neoplasms.