Insulin-like growth factor 1 levels predict weight loss in women post laparoscopic sleeve gastrectomy

The study aimed to assess the association between insulin-like growth factor 1 (IGF-1) levels and weight loss in female patients post laparoscopic sleeve gastrectomy (SG). It included 100 patients who underwent clinical and laboratory investigations, with follow-up after one year. Results showed a significant reduction in body mass index, fasting HbA1c levels, and triglycerides, along with an increase in HDL and IGF-1 levels. Multiple regression analysis revealed that baseline IGF-1 levels were a crucial predictor of optimal initial clinical response. An IGF-1 cutoff value of ≤23 ng/ml detected suboptimal response with high accuracy.