Comparative Outcomes and Prognostic Factors in Adrenalectomy for Adrenal Metastasis

Adrenalectomy for adrenal metastasis remains controversial, and the feasibility of laparoscopic adrenalectomy (LA) is under debate. A retrospective review of 141 patients undergoing adrenalectomy compared open adrenalectomy (OA) to LA. For tumors less than 8 cm without adjacent organ resection, LA had shorter operation time, less blood loss, and shorter hospital stay. Positive pathological margin, disease activity at the primary site, other metastases, and larger tumor size were associated with poor locoregional recurrence-free survival. Metachronous metastasis was linked to longer overall survival, while positive pathological margin, metastases to other organs, and larger tumor size were associated with shorter overall survival.