In colorectal liver metastases (CRLM), the review investigates the association between KRAS status, histopathological growth patterns (HGPs), and their impact on resection margins around major vasculature and bile ducts. The study emphasizes the importance of balancing negative margins and preserving vascular and biliary structures during surgery. While parenchymal sparing is crucial, the review explores how KRAS and HGPs contribute to prognostication after resection, shedding light on their influence on overall survival and recurrence rates.
Review by Wong P, Wong GYM (…) Hugh TJ et 2 al. in ANZ J Surg
© 2024 The Authors. ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.