Ki-67 Proliferation Index as a Potential Surrogate for Tumor Grade in Pleural Epithelioid Mesotheliomas

Ki-67 proliferation index was found to be associated with tumor grade in pleural epithelioid mesotheliomas, showing comparable predictability for overall survival to mitotic score. High Ki-67 index and mitoses were significantly linked to poor overall survival, suggesting that Ki-67 index by digital image analysis could serve as a reliable surrogate for tumor grade in assessing prognosis for patients with pem.