Complete liver splitting along the demarcation line induced higher portal vein pressure and more rapid future liver remnant hypertrophy than partial or ectopic liver splitting after portal vein ligation in a rat model. The portal hemodynamic alterations, rather than inflammatory cytokine release, played a significant role in accelerating liver hypertrophy. Extrahepatic organ injury, such as spleen ablation, also impacted portal hemodynamics and liver regeneration.
Journal Article by Chen X, Zhou B (…) Chen G et 4 al. in BMC Surg
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