Preoperative Chemoradiotherapy Reduces Pancreatic Fistula Risk

Preoperative chemoradiotherapy, but not chemotherapy, was found to be associated with a reduced risk of postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Out of the 2,019 patients included in the study, postoperative pancreatic fistula occurred in 8.3% after immediate surgery, 4.2% after preoperative chemotherapy, and 2.0% after preoperative chemoradiotherapy. These findings highlight the importance of considering preoperative chemoradiotherapy for reducing complications in pancreatic cancer surgery.