Histological Growth Pattern Predicts Survival in Peritoneal Metastases
Patients with colorectal peritoneal metastases who underwent cytoreductive surgery had better disease-free and overall survival if they had a dominant pushing histological growth pattern compared to infiltrating pattern. The study confirmed the prognostic value of these patterns regardless of neoadjuvant chemotherapy or extent of peritoneal disease burden. No significant associations were found between neoadjuvant chemotherapy and the type of histological growth pattern.
In patients with gastric cancer and positive peritoneal lavage cytology or localized peritoneal metastasis, upfront chemotherapy followed by surgery yields better outcomes than surgery followed by chemotherapy.
Secondary cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improves survival for select patients with recurrent colorectal cancer peritoneal metastases.
