Factors influencing late recurrence and survival outcomes in hepatocellular carcinoma patients post-resection

Analysis of 1,701 patients with hepatocellular carcinoma after curative resection revealed 38.4% experienced late recurrence, with median time to recurrence of 4.0 years. Risk factors for late recurrence included age >60, chronic hepatitis C, cirrhosis, high albumin-bilirubin grade, absence of family history, and specific tumor characteristics. Surgical treatment was associated with better survival outcomes post-recurrence. Early identification and treatment of risk factors, particularly underlying hepatitis, are crucial for improving long-term outcomes.