Obesity and Adiposity Distribution: Causal Factors for Ventral Hernia

Obesity measures and abdominal adiposity indicators were evaluated using Mendelian randomization to determine their causal relationship with ventral hernia (VH) risk. Increased BMI, body fat percentage, body fat mass, visceral adiposity tissue, waist circumference, and hip circumference were found to be causally associated with a higher risk of VH. Body fat percentage remained a significant factor even after adjusting for confounding variables. These results emphasize the importance of fat distribution in understanding the mechanism of VH.