Three-Year Outcomes of Oral Antibiotics vs Intravenous and Oral Antibiotics for Uncomplicated Acute Appendicitis
Current short-term evidence suggests that oral antibiotics alone can successfully treat uncomplicated acute appendicitis. A study comparing oral antibiotic monotherapy with combined IV and oral antibiotics over a longer-term follow-up found no significant difference in treatment success rate at year 3. While a slightly higher appendectomy rate was observed with oral antibiotic monotherapy, noninferiority could not be demonstrated. Future studies are warranted to explore oral antibiotic monotherapy as a viable treatment option.
Patients who needed emergency general surgery within 60 days of a pulmonary embolism had more major complications than those operated on later, in a national database study.
Among 3,785 patients who had emergency general surgery after acute pulmonary embolism, those operated on at least 60 days later had markedly fewer major adverse events (adjusted OR 0.45, 95% CI 0.37–0.55).
Appendix, Gallbladder and Surgical Emergencies3 Nov 2026
