Bromelain enhances cytotoxicity and mucolytic activity in appendiceal cancer tumors, reducing mucin production and increasing drug effectiveness in heated intraperitoneal chemotherapy (HIPEC) treatments. Combined with N-acetylcysteine, bromelain significantly reduces mucin levels and boosts cell death pathways like apoptosis and autophagy. These findings suggest a promising role for bromelain as a potent pretreatment agent in augmenting HIPEC outcomes for appendiceal cancer patients.
Journal Article by Wajih N, Erali RA (…) Votanopoulos KI et 6 al. in Ann Surg Oncol
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