Genetic Background Influence on Weight Loss After Bariatric Surgery

Individuals with lower polygenic risk scores experienced better weight loss outcomes after bariatric surgery compared to those with higher scores, especially in patients undergoing roux-en-y gastric bypass. Genetic background, assessed through polygenic risk scores, plays a significant role in long-term weight loss post-surgery, alongside factors like sex, age, and initial BMI. These findings suggest the potential of utilizing genetic risk scores to predict bariatric surgery outcomes.