Beneficial outcomes of total pancreatectomy with islet autotransplantation in genetic pancreatitis

Total pancreatectomy with islet autotransplantation (TPIAT) provides beneficial metabolic and pain relief outcomes in patients with genetic chronic pancreatitis. Patients with genetic etiology undergo TPIAT at a younger age, experience longer symptom duration, and yield lower islet mass, yet maintain similar metabolic function post-transplant. Post-TPIAT, narcotic usage and pain scores significantly decrease, with more genetic patients achieving pain and narcotic freedom. Early consideration of TPIAT in genetic chronic pancreatitis is supported by these findings.