Thyroglobulin Wash-Out for Lymph Node Metastasis in Thyroid Carcinoma

Thyroglobulin wash-out after fine-needle aspiration cytodiagnosis effectively evaluates lymph node metastasis in papillary thyroid carcinoma. A cutoff value of 3.2 ng/ml for FNA-TG offers higher accuracy and lower false negatives than single diagnoses. Combining FNAC with FNA-TG increases sensitivity, though specificity decreases slightly. Ultrasonography provides dynamic LN assessment, enhancing diagnostic efficacy without added patient discomfort. Presence of TG in normal lymphocytes near cancer is confirmed, supporting clinical value.