Delaying adjuvant chemotherapy for more than 6 weeks post colorectal cancer surgery is associated with worse disease-free survival in high-risk stage II and III patients. A study of 5719 individuals revealed a 5-year disease-free survival of 78.0% vs. 73.2% in early vs. late-start groups, respectively. Those initiating chemotherapy later had a hazard ratio of 1.24 for worse outcomes. No significant difference in adverse events was observed between the groups.
Journal Article by Gögenur M, Rosen AW (…) Holländer NH et 29 al. in JAMA Surg