HPB & Spleen · 5 July 2024

Large duct-type ICCA shows worse survival rates and unique genetic features

Large duct-type ICCA exhibits worse overall and recurrence-free survival rates compared to small duct-type ICCA. Mutational landscape analysis revealed distinct genetic alterations, with specific mutations in ARID1A, DOT1L, and ELF3 more common in large duct-type ICCA, while mutations in IDH1 and BAP1 were prevalent in small duct-type ICCA. The overexpression of PPP1R1B in large duct-type ICCA suggests its potential as a marker and therapeutic target.

Journal Article by Chen Z, Gao J (…) Li Z et 5 al. in Liver Int

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