Bariatric surgery significantly lowers PAI-1 levels, which correlate with improvements in lipids, glucose, and insulin resistance. The surgery also induces a decrease in body weight and BMI, and helps reverse type 2 diabetes. PAI-1 acts as a regulator of PCSK9, TG, and BMI, while PCSK9 modulates LDL-C, HDL-C, and PAI-1. These changes suggest an improved balance in cholesterol and a reduction in factors contributing to atherosclerosis and cardiovascular disease in obesity.
Journal Article by Castro-Leyva V, Manuel-Apolinar L (…) Martínez-Murillo C et 4 al. in Arch Med Res
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