Evaluation of tumor necrosis as a prognostic indicator in colorectal cancer led to the development of criteria for three assessment methods: average percentage, hotspot, and linear methods. All methods demonstrated independent predictive ability for colorectal cancer-specific survival, with the average percentage method showing the highest hazard ratios. Reproducibility assessments revealed strong agreement among investigators, particularly for the linear method, indicating that tumor necrosis evaluation can be reliably integrated into clinical practice.
• Why it matters: Improved prognostic tools are needed for better cancer outcomes.
Journal Article by Kastinen M, Sirniö P (…) Väyrynen JP et 21 al. in Am J Surg Pathol
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