A single high dose of intravenous dexamethasone prior to emergency laparotomy significantly reduces postoperative inflammatory responses, as shown by lower C-reactive protein levels (median 170 vs. 220 mg/l, p = 0.015). This administration correlates with enhanced recovery indicators, such as improved hemodynamics and earlier mobilization. The dexamethasone group also experienced a notable decrease in 90-day mortality (7% vs. 23%, p = 0.023) and major complications (27% vs. 45%, p = 0.032), suggesting substantial clinical benefits.
• Why it matters: Reducing inflammation can significantly improve postoperative outcomes.
Randomized Controlled Trial by Cihoric M, Kehlet H (…) Foss NB et 4 al. in Br J Surg
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