A systematic review and meta-analysis of 12 randomized clinical trials involving 903 patients indicate that delayed primary skin closure (DPC) significantly lowers the risk of surgical site infections (SSI) following surgery for gastrointestinal perforation, with an odds ratio of 0.31 (p < 0.01). However, no significant differences in length of stay (LOS) were found between DPC and primary closure (PC) groups. These findings support DPC as an effective strategy for managing severely contaminated surgical wounds.
Review by Zhang C, Zhou J (…) Li R et 5 al. in Langenbecks Arch Surg
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