Administration of dexmedetomidine before surgery markedly lowered serum levels of stress-related biomarkers in patients undergoing ENT procedures. A study involving 100 patients revealed that those receiving dexmedetomidine experienced significant reductions in cortisol, TNF-α, and interleukin-6 levels compared to a control group, with values dropping from 139.73 to 10.18, 99.51 to 0.96, and 85.09 to 0.96, respectively. The intervention also contributed to smoother recovery without nausea or vomiting.
Journal Article by Ajmal K, Waheed A, Farooqi R and Mansoor Q in Pak J Med Sci
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