Laparoscopic cholecystectomy is optimal for pregnant patients with gallbladder disease

In a systematic review of 63,523 pregnant women, laparoscopic cholecystectomy (LC) emerged as the most favorable treatment for gallbladder disease. It significantly reduced risks of preterm delivery (RR: 0.23), fetal complications (RR: 0.42), and maternal complications (RR: 0.44) compared to open cholecystectomy. While cholecystectomy is safe in any trimester, the third trimester poses heightened maternal risk, necessitating cautious evaluation before proceeding. These findings highlight the importance of treatment timing in managing gallbladder issues during pregnancy.