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Eosinophil counts are causally linked to pancreatic cancer.

A comprehensive study using MR-PheWAS and mendelian randomization demonstrated a causal association between pancreatic cancer and eosinophil counts, highlighting a notable correlation. Among 776 phenotypes analyzed, 41 showed significance, with specially validated results indicating that genetically predicted pancreatic cancer was linked to elevated eosinophils. This suggests a self-reinforcing relationship between the two. The findings call for further investigations into these associations, giving insights into pancreatic cancer’s potential predictors and underlying mechanisms.

Systematic Review by Guan A, Li Z and Guo X in Medicine (Baltimore)

Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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