Prophylactic closure of mucosal defects significantly reduces delayed bleeding and perforation risks following endoscopic resection, according to a systematic review and meta-analysis of 28 studies involving 11,383 patients. The closure group exhibited a 60% lower risk for delayed bleeding compared to non-closure (risk ratio: 0.40), although no significant reduction in postpolypectomy coagulation syndrome (PPCS) was observed. These findings underscore the potential benefits of closure in improving patient outcomes in gastrointestinal procedures.
Meta-Analysis by Yi S, Cai Q (…) Yang D et 7 al. in BMJ Open
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