Better IPMN risk stratification could optimize cancer surgery decisions.

Personalized Cancer Risk Thresholds Can Guide IPMN Surgery Decisions

Clinicians found that optimal cancer risk thresholds (CRT) for surgery in patients with branch-duct intraductal papillary mucinous neoplasms (bd-IPMN) vary based on age, comorbidities, and tumor location. For a 60-year-old with mild comorbidities, surgery was favored at a 20% CRT for tumors in the pancreatic head and 3% in the tail, yielding a slight QALY advantage (21.90 vs. 21.88). These personalized thresholds may improve surgical decision-making and refine guidelines, balancing cancer risk against surgical complications.

Journal Article by Sacks GD, Wojtalik L (…) Braithwaite RS et 6 al. in HPB (Oxford)

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