Key pharmacotherapy strategies enhance outcomes in colorectal surgery

A causal model identifies pharmacotherapy methods that improve outcomes for elective colorectal surgery patients. Key strategies associated with better primary and secondary composite outcomes include prehospital oral iron and antibiotics, postoperative sugammadex and neostigmine, limiting morphine to ≤50 MME, and ceasing IV fluids by postoperative day two. Contrarily, preoperative scopolamine patches and perioperative gabapentin showed lesser odds for positive outcomes, emphasizing the need for tailored pharmacotherapy in enhanced recovery programs. Further research is warranted on certain treatment impacts.