Subscribe free

Intestine and Lower Gastrointestinal Tract ·

Mature tertiary lymphoid structures indicate better prognosis in colorectal cancer.

Colorectal cancer patients with mature tertiary lymphoid structures (TLS) demonstrated notably improved outcomes, including reduced rates of vascular tumor thrombus, lymph node, and liver metastasis. An analysis of 230 specimens revealed that mature TLS correlated with lower Ki-67 expression and higher levels of deficient mismatch repair and PD-L1 positivity. These findings suggest that TLS maturation plays a crucial role in patient prognosis and may inform strategies for immunotherapy and prognostic evaluations in colorectal cancer.

Journal Article by Zheng J, Yu J (…) Deng H et 2 al. in Zhejiang Da Xue Xue Bao Yi Xue Ban

read the whole article in Zhejiang Da Xue Xue Bao Yi Xue Ban

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in Intestine and Lower Gastrointestinal Tract.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

Specialty newsletters: every new paper in your field, as a list of titles linked to the source. Daily Selection: the five that matter, cut to their key points.

FreeNo spamOne-click unsubscribe

More in Intestine and Lower Gastrointestinal Tract

The latest stitches

Lancet4 Nov 2026

Colorectal cancer: shorter chemo, fewer side effects

A Japanese randomized trial found that a 14-day schedule of trifluridine-tipiracil plus bevacizumab keeps patients with metastatic colorectal cancer alive as long as the standard 28-day schedule, with far less toxicity.

Br J Surg4 Nov 2026

Robot matches laparoscopy for rectal cancer survival

Five years after surgery for low rectal cancer, patients operated on robotically did as well as those operated on laparoscopically, according to a randomized trial from three Korean centres.

All papers in Intestine and Lower Gastrointestinal Tract →